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Peer-Reviewed Publication
JAACAP Open2025;3(4):1033-1045.December 1, 2025Journal Article

A Relational Agent Intervention for Adolescents Seeking Mental Health Treatment: Outcomes From a Randomized Controlled Trial Within a Children's Outpatient Hospital.

Mary Margaret Gleason1, Megan Flom2, Stephanie Rapoport2, Andre Williams2, Autumn Birch2, Nicole K Wells1, Valerie Forman-Hoffman2, Athena Robinson2
1Children's Hospital of The King's Daughters and Eastern Virginia Medical School, Norfolk, Virginia.
2Woebot Health, San Francisco, California.

Abstract

OBJECTIVE: Despite steady increases in the prevalence of depression and anxiety, many adolescents remain undertreated. Digital mental health interventions (DMHI) may address some barriers to care. This study is the first to examine the prospective noninferiority of a smartphone-based, self-guided relational agent (W-GenZD) DMHI to address adolescent depressive symptoms compared to group-based tele…

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