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Neuroimage2026;325121637.January 1, 2026Journal Article

Quantitative neuroimaging meets normative modelling: the last mile for precision medicine applications.

Lucia Maccioni1, Alessio Giacomel2, Marco Pinamonti3, Mattia De Francisci3, Federico Del Pup4, Alice Giubergia5, Giulia Vallini3, Valentina Visani3, Leonardo Barzon3, Ottavia Dipasquale6, Alessandra Bertoldo7, Manuela Moretto8, Mattia Veronese9
1Department of Information Engineering, University of Padova, Padova, Italy. Electronic address: lucia.maccioni.1@phd.unipd.it.
2Department of Child and Adolescent Psychiatry, University Hospital, Goethe University, Frankfurt am Main, Germany; Cooperative Brain Imaging Centre (COBIC), Goethe University, Frankfurt am Main, Germany; Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, United Kingdom.
3Department of Information Engineering, University of Padova, Padova, Italy.
4Department of Information Engineering, University of Padova, Padova, Italy; Padova Neuroscience Center (PNC), University of Padova, Padova, Italy; Department of Neuroscience (DNS), University of Padova, Padova, Italy.
5Department of Information Engineering, University of Padova, Padova, Italy; Neuroimaging Unit, Scientific Institute IRCCS Eugenio Medea, Bosisio Parini, Italy.
6Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, United Kingdom; Department of R&D Advanced Applications, Olea Medical, La Ciotat, France.
7Department of Information Engineering, University of Padova, Padova, Italy; Padova Neuroscience Center (PNC), University of Padova, Padova, Italy.
8Department of Information Engineering, University of Padova, Padova, Italy; Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, United Kingdom.
9Department of Information Engineering, University of Padova, Padova, Italy; Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, United Kingdom. Electronic address: mattia.veronese@unipd.it.
PubMed DOI

Abstract

Quantitative neuroimaging techniques have proven to be powerful tools for studying normal brain physiology and investigating the structural and functional alterations associated with different brain disorders. Despite their huge potential, their contribution to the clinic has largely been limited to supporting (when possible) more standardised neuroradiological imaging procedures. Traditionally, q…

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