Peer-Reviewed Publication
Diagn Progn Res2025;9(1):29.December 5, 2025Letter

Explainable AI in healthcare: to explain, to predict, or to describe?

Alex Carriero1, Anne de Hond2, Bram Cappers3, Fernando Paulovich3, Sanne Abeln4, Karel Gm Moons2, Maarten van Smeden2
1Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. a.j.carriero@umcutrecht.nl.
2Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
3Department of Mathematics and Computer Science, Eindhoven University of Technology, Eindhoven, The Netherlands.
4Department of Information and Computing Sciences, Utrecht University, Utrecht, The Netherlands.

Abstract

Explainable Artificial Intelligence (AI) methods are designed to provide information about how AI-based models make predictions. In healthcare, there is a widespread expectation that these methods will provide relevant and accurate information about a model's inner-workings to different stakeholders (ranging from patients and healthcare providers to AI and medical guideline developers). This is a…

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