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Peer-Reviewed Publication
Circ Heart Fail2026;19(2):e013231.February 1, 2026Journal Article

Digital Platform to Optimize Guideline-Directed Heart Failure Therapy: Results of the AIM-POWER Trial.

Adam D DeVore1, Maulik Majmudar2, Leigh Etters2, Jiecheng Xie2, Chen Hao2, Phillip H Lam3, Adrian F Hernandez1, Gregg C Fonarow4, Akshay S Desai5
1Duke Clinical Research Institute and Department of Medicine, Duke University School of Medicine, Durham, NC (A.D.D., A.F.H.).
2Biofourmis Inc, Nashville, TN (M.M., L.E., J.X., C.H.).
3Georgetown University and Department of Cardiology, MedStar Washington Hospital Center, Washington, DC (P.H.L.).
4Division of Cardiology, Department of Medicine, Ronald Reagan-UCLA Medical Center, Los Angeles, CA (G.C.F.).
5Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (A.S.D.).

Abstract

BACKGROUND: Less than 1 in 3 patients in the United States with heart failure (HF) with reduced ejection fraction are receiving guideline-recommended medical therapy. Remote titration programs outside of structured episodes of care may address this issue and improve the implementation of guideline-recommended care. METHODS: AIM-POWER (Artificial Intelligence Mobile Health Trial of a Digital Platf…

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