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Transl Psychiatry2025;16(1):17.November 26, 2025Journal Article

Remote monitoring of wide-ranging real-world changes in adults following ADHD medication initiation.

Yuezhou Zhang1, Alice Barnes2, Kanyakorn Veerakanjana2,3, Hayley Denyer2,4, Heet Sankesara5, Hannah Marriott2, Phoebe Rocks2, Giulia Gerboni6, Andrea Mortera6, Ulrich Müller-Sedgwick7,8, Susannah Whitwell9, Henrik Larsson10,11, Amos Folarin5,12,13,14,15, Josep Antoni Ramos-Quiroga16,17,18,19, Richard Jb Dobson5,12,13,14,15, Jonna Kuntsi2
1Department of Biostatistics & Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. yuezhou.zhang@kcl.ac.uk.
2Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
3Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
4Department of Child & Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
5Department of Biostatistics & Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
6Empatica Srl, Milan, Italy.
7Department of Psychiatry, University of Cambridge, Cambridge, UK.
8Health and Community Services, Government of Jersey, St Helier, Jersey.
9South London and Maudsley NHS Foundation Trust, London, UK.
10School of Medical Sciences, Orebro University, Orebro, Sweden.
11Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden.
12Institute of Health Informatics, University College London, London, UK.
13NIHR Biomedical Research Centre at South London and Maudsley NHS Foundation Trust, London, UK.
14NIHR Biomedical Research Centre at University College London Hospitals NHS Foundation Trust, London, UK.
15Health Data Research UK, University College London, London, UK.
16Department of Psychiatry, Hospital Universitari Vall d'Hebron, Barcelona, Catalonia, Spain.
17Psychiatry, Mental Health and Addictions Group, Vall d'Hebron Research Institute (VHIR), Instituto de Investigación Sanitaria Acreditado Instituto de Investigación - Hospital Universitario Vall d'Hebron (IR-HUVH), Barcelona, Catalonia, Spain.
18Biomedical Network Research Centre on Mental Health (CIBERSAM), Barcelona, Catalonia, Spain.
19Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain.
PubMed PMC DOI PDF

Abstract

While attention-deficit/hyperactivity disorder (ADHD) medication is effective for core symptoms, its broader and progressive impacts remain underexplored. This study evaluated real-world changes in ADHD symptoms and impairments, co-occurring psychiatric symptoms, physical measures, and health behaviors following ADHD medication initiation in adults. Data were drawn from a remote monitoring cohort…

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