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Peer-Reviewed Publication
Can J Ophthalmol2026;61(3):506-517.June 1, 2026Journal Article

Clinical utility of an AI-based retinal imaging model for cardiovascular risk prediction in hypertensive retinopathy.

Dongjin Nam1, Yong-Hwan Jang1, Yongseok Lee1, Jaewon Seo2, Sahil Thakur3, Simon Nusinovici4, Moonsu Kim5, Yong Un Shin5, Hwan-Cheol Park6, Sunjin Hwang7
1Mediwhale Inc., Seoul, South Korea; Department of Internal Medicine, Graduate School, Yonsei University College of Medicine, Seoul, South Korea.
2Mediwhale Inc., Seoul, South Korea.
3Mediwhale Inc., Seoul, South Korea; Singapore Eye Research Institute/Singapore National Eye Center, Singapore.
4Mediwhale Inc., Seoul, South Korea; Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore.
5Noon eye clinic, Guri city, South Korea.
6Division of Cardiology, Department of Internal Medicine, Hanyang University Guri Hospital, Guri City, South Korea.
7Department of Ophthalmology, Hanyang University College of Medicine, Seoul, South Korea; Department of Ophthalmology, Hanyang University Guri Hospital, Guri city, South Korea. Electronic address: sunjin1989@hanyang.ac.kr.

Abstract

OBJECTIVE: This study presents an independent clinical evaluation of Dr.Noon CVD, a commercially developed artificial intelligence (AI)-based retinal imaging model that estimates cardiovascular disease (CVD) risk. We assessed whether the model can effectively evaluate CVD risk in patients with hypertensive retinopathy (HR), a population in which the applicability of conventional CVD risk models re…

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