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Peer-Reviewed Publication
J Biomech Eng2026;148(2)February 1, 2026Journal Article

Bridging the Gap Between Species: Translating a Fracture Callus Mechanical Properties Model From Ovine to Human Use.

Mehran Bahrami1,2, Brendan Inglis3,4, Hannah L Dailey1
1Department of Mechanical Engineering and Mechanics, Lehigh University, Packard Laboratory, 19 Memorial Drive West, Bethlehem, PA 18015.
2Lehigh University.
3Globus Medical Inc., 2550 General Armistead Avenue, Norristown, PA 19403.
4Globus Medical (United States).
PubMed DOI

Abstract

New approach methodologies (NAMs) can reduce reliance on animal testing and enable outcomes assessments in humans that were previously possible only in animal studies. Translating NAMs from animals to clinical use requires consideration of differences between the preclinical and clinical settings. The objective of this study was to translate and assess the performance of virtual mechanical testing…

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