Network-based disease fingerprinting with neuroinflammation PET imaging.

Leonardo Barzon¹, Lucia Maccioni¹, Michelle Carranza Mellana², Julia J Schubert³, Ludovica Brusaferri⁴, Oliver Cousins³, Ivana Rosenzweig³, Yuya Mizuno³, Tiago Reis Marques⁵, Neil A Harrison⁶, Tim Fryer⁷, Edward T Bullmore⁸, Valeria Mondelli³, Carmine Pariante³, David Sharp⁹, Gregory Scott⁹, Joana B Pereira¹⁰, Oliver Howes³, Vesna Sossi¹¹, Benedetta Bodini², Bruno Stankoff², Marco L Loggia¹², Federico E Turkheimer³, Mattia Veronese¹

¹Department of Information Engineering, University of Padova, Padova, Italy.

²Paris Brain Institute, ICM, CNRS, Inserm, Sorbonne Université, Paris, France.

³Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK.

⁴Computer Science and Informatics, School of Engineering, London South Bank University, London, UK.

⁵Psychiatric Imaging Group, MRC London Institute of Medical Sciences (LMS), Hammersmith Hospital, Imperial College London, London, UK.

⁶Cardiff University Brain Research Imaging Centre (CUBRIC), Cardiff University, Cardiff, UK.

⁷Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Cambridge, UK.

⁸Department of Psychiatry, School of Clinical Medicine, University of Cambridge, Cambridge, UK.

⁹Division of Brain Sciences, Department of Medicine, Imperial College London, UK.

¹⁰Division of Neuro, Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.

¹¹Department of Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada.

¹²Departments of Radiology and Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

PubMed PMC DOI PDF

Abstract

Neuroinflammation is a hallmark of numerous neurodegenerative, psychiatric, and chronic pain disorders and can be assessed in vivo with 18 kDa translocator protein (TSPO) positron emission tomography (PET). However, conventional quantification methods of TSPO PET are limited and often overlook the spatial relationships between regional signals. The application of network-based approaches to TSPO P…

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