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Peer-Reviewed Publication
Wounds2025;37(10):384-392.October 1, 2025Journal Article

Advancing chronic wound care with near-infrared spectroscopy imaging: clinical applications, measurement parameters, and insights into healing dynamics.

Alisha Oropallo1, Alex G Ortega-Loayza2, Holly Korzendorfer3, Francis James4, Peggy Dotson5, Anna Khimchenko6, Vickie R Driver7, Sharon Eve Sonenblum8
1Department of Vascular Surgery, Donald and Barbara Zucker School of Medicine, Hofstra/Northwell, Hempstead, NY, USA; Feinstein Institutes for Medical Research, Manhasset, NY, USA; Comprehensive Wound Healing Center, Department of Vascular and Endovascular Surgery, Northwell Health, Lake Success, NY, USA; Wound Care Collaborative Community, Orlando, FL, USA.
2Wound Care Collaborative Community, Orlando, FL, USA; Department of Dermatology, Oregon Health and Science University, Portland, OR, USA.
3Wound Care Collaborative Community, Orlando, FL, USA; Doctor of Physical Therapy Program, Marist University, Poughkeepsie, NY, USA.
4Wound Care Collaborative Community, Orlando, FL, USA; TRUE-See, New Orleans, LA, USA.
5Wound Care Collaborative Community, Orlando, FL, USA.
6Wound Care Collaborative Community, Orlando, FL, USA; MIMOSA Diagnostics Inc, Toronto, ON, Canada.
7Wound Care Collaborative Community, Orlando, FL, USA; Washington State University Elson S. Floyd College of Medicine, Spokane, WA, USA.
8Wound Care Collaborative Community, Orlando, FL, USA; Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA, USA.

Abstract

BACKGROUND: Chronic wound management is a global health care challenge affecting patient morbidity and quality of life while presenting a substantial economic burden. A critical limitation in effective wound care is the inability to accurately assess microvascular tissue health in real time. This review of near-infrared spectroscopy (NIRS) imaging and its use in wound care emphasizes relevant clin…

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