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Peer-Reviewed Publication
Heart Rhythm2026;23(3):e357-e367.March 1, 2026Journal Article

Targetable atrial tachycardias after artificial intelligence-guided ablation of persistent atrial fibrillation.

Isabel Deisenhofer1, Julien Seitz2, Sabine Lotteau3, Jean-Paul Albenque4, Sonia Busch5, Marie-Sophie Nguyen-Tu3, Amélie Dayot3, Mélanie Dalmau3, Hanna Leukovich3, Clément Bars2, Tom De Potter6, Christian de Chillou7, Seth Goldbarg8, Anthony Appetiti3, Paola Milpied3, Théophile Mohr Durdez3, John D Hummel9, Jérôme Kalifa10
1Department of Electrophysiology, Technical University of Munich, German Heart Center Munich, Munich, Germany.
2Saint Joseph Hospital, Marseille, France.
3Volta Medical, Marseille, France.
4Clinique Pasteur, Toulouse, France.
5Department of Electrophysiology, Herz-Zentrum Bodensee, Constance, Germany.
6Cardiovascular Center, Onze Lieve Vrouwziekenhuis Hospital, Aalst, Belgium.
7Département de Cardiologie, CHU de Nancy, Nancy, France.
8New York Presbyterian Queens Division of Cardiology, Flushing, New York.
9The Ohio State University Wexner Medical Center, Columbus, Ohio.
10Volta Medical, Marseille, France. Electronic address: jerome.kalifa@volta-medical.com.

Abstract

BACKGROUND: The TAILORED-AF randomized trial demonstrated that artificial intelligence-guided ablation of spatiotemporal dispersion in addition to pulmonary vein isolation significantly reduced atrial fibrillation (AF) recurrence at 1-year follow-up in patients with persistent AF. Still, approximately one-third of the population experienced atrial tachycardia (AT) recurrences, most of which were s…

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