Peer-Reviewed Publication
Neuroimage2025;323121585.December 1, 2025Journal Article
Regular cannabis use modulates gamma functional connectivity with V1 during visual processing.
Lauren K Webert1, Nathan M Petro2, Seth D Springer3, Jason A John4, Lucy K Horne5, Molly E Voller6, Kyla R De Luca7, Olivia R Carusi8, Lan D Volberding9, Grant M Garrison10, Hannah J Okelberry11, Ryan Glesinger12, Maggie P Rempe13, Tony W Wilson14
1Institute for Human Neuroscience, Boys Town National Research Hospital, 14090 Mother Teresa Ln, Boys Town, NE 68101, USA. Electronic address: lauren.webert@boystown.org.
2Institute for Human Neuroscience, Boys Town National Research Hospital, 14090 Mother Teresa Ln, Boys Town, NE 68101, USA. Electronic address: Nathan.Petro@boystown.org.
3Institute for Human Neuroscience, Boys Town National Research Hospital, 14090 Mother Teresa Ln, Boys Town, NE 68101, USA; College of Medicine, University of Nebraska Medical Center, 4400 Emile Street Omaha, NE 68198, USA. Electronic address: seth.springer@unmc.edu.
4Institute for Human Neuroscience, Boys Town National Research Hospital, 14090 Mother Teresa Ln, Boys Town, NE 68101, USA. Electronic address: jason.john@boystown.org.
5Institute for Human Neuroscience, Boys Town National Research Hospital, 14090 Mother Teresa Ln, Boys Town, NE 68101, USA. Electronic address: lhorne20@charlotte.edu.
6Institute for Human Neuroscience, Boys Town National Research Hospital, 14090 Mother Teresa Ln, Boys Town, NE 68101, USA. Electronic address: molly.voller@boystown.org.
7Institute for Human Neuroscience, Boys Town National Research Hospital, 14090 Mother Teresa Ln, Boys Town, NE 68101, USA. Electronic address: kyla.deluca@boystown.org.
8Institute for Human Neuroscience, Boys Town National Research Hospital, 14090 Mother Teresa Ln, Boys Town, NE 68101, USA. Electronic address: olivia.carusi@boystown.org.
9Institute for Human Neuroscience, Boys Town National Research Hospital, 14090 Mother Teresa Ln, Boys Town, NE 68101, USA. Electronic address: lan.volberding@boystown.org.
10Institute for Human Neuroscience, Boys Town National Research Hospital, 14090 Mother Teresa Ln, Boys Town, NE 68101, USA. Electronic address: Grant.Garrison@boystown.org.
11Institute for Human Neuroscience, Boys Town National Research Hospital, 14090 Mother Teresa Ln, Boys Town, NE 68101, USA. Electronic address: hannah.okelberry@boystown.org.
12Institute for Human Neuroscience, Boys Town National Research Hospital, 14090 Mother Teresa Ln, Boys Town, NE 68101, USA. Electronic address: Ryan.Glesinger@boystown.org.
13Institute for Human Neuroscience, Boys Town National Research Hospital, 14090 Mother Teresa Ln, Boys Town, NE 68101, USA; College of Medicine, University of Nebraska Medical Center, 4400 Emile Street Omaha, NE 68198, USA. Electronic address: maggie.rempe@unmc.edu.
14Institute for Human Neuroscience, Boys Town National Research Hospital, 14090 Mother Teresa Ln, Boys Town, NE 68101, USA; College of Medicine, University of Nebraska Medical Center, 4400 Emile Street Omaha, NE 68198, USA; Department of Pharmacology and Neuroscience, Creighton University, 2500 California Plz, Omaha, NE 68178, USA. Electronic address: tony.wilson@boystown.org.
Abstract
Cannabis is a widely-used illicit substance in the United States, and heavy cannabis use has been linked to deficits across multiple cognitive domains. Mechanistically, cannabis affects endocannabinoid receptors densely distributed among GABAergic interneurons throughout the cortex and cerebellum. Such interneuronal networks are known to be crucial in the generation of fast neural gamma-band respo…
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