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Stroke2026;57(2):514-525.February 1, 2026Journal Article

Optimizing Reperfusion Trials: A Consensus Research Roadmap From the STAIR XIII Conference.

Bruce C V Campbell1,2, Yasmin N Aziz3, George W J Harston4, Opeolu Adeoye5, Pooja Khatri6, Urs Fischer7, Yunyun Xiong8, Andrei V Alexandrov9, Gregory C Makris10,11, Jean-Claude Baron12, Felix C Ng1,13, Adrien Ter Schiphorst14, Thanh N Nguyen15, Santiago Ortega-Gutierrez16, Carolina Maier17, Liping Liu, Michael D Hill18, Gregory W Albers19, Jeremy J Heit20,
1Department of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital (B.C.V.C., F.C.N.), University of Melbourne, Parkville, Victoria, Australia.
2Florey Institute of Neuroscience and Mental Health (B.C.V.C.), University of Melbourne, Parkville, Victoria, Australia.
3Department of Neurology, University of Cincinnati, OH (Y.N.A.).
4Acute Stroke Service, Oxford University Hospitals National Health Service Foundation Trust, United Kingdom (G.W.J.H.).
5Department of Emergency Medicine, Washington University, St. Louis, MO (O.A.).
6Department of Neurology, Yale School of Medicine, Yale University, New Haven, CT (P.K.).
7Department of Neurology, University Hospital Bern and University of Bern, Switzerland (U.F.).
8Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China (Y.X., L.L.).
9Department of Neurology, University of Arizona College of Medicine-Phoenix and Banner University Medical Center, Phoenix (A.V.A.).
10Vascular and Thrombosis Therapeutic Division, Bayer Pharmaceuticals, Leverkusen, Germany (G.C.M.).
11Department of Vascular and Interventional Radiology, Guys' and St Thomas Hospital, National Health Service Foundation Trust, London, United Kingdom (G.C.M.).
12Department of Neurology, Le Groupe Hospitalier Universitaire (GHU) Paris Psychiatrie et Neurosciences, Inserm U1266, Université Paris Cité, France (J.-C.B.).
13Department of Neurology, Austin Health, Heidelberg, Victoria, Australia (F.C.N.).
14Department of Neurology, Montpellier University Hospital, Montpellier, and Inserm U1266, Paris, France (A.t.S.).
15Department of Neurology, Boston Medical Center, Boston University Chobanian and Avedisian School of Medicine, MA (T.N.N.).
16Departments of Neurosurgery and Radiology, University of Iowa Hospitals and Clinics (S.O.-G.).
17RapidAI, Menlo Park, CA (C.M.).
18Department of Clinical Neurosciences and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Alberta, Canada (M.D.H.).
19Department of Neurology and Stanford Stroke Center (A.t.S., G.W.A.), Stanford University School of Medicine, CA.
20Department of Radiology and Stanford Stroke Center (J.J.H.), Stanford University School of Medicine, CA.
PubMed DOI

Abstract

The STAIR (Stroke Treatment Academic Industry Roundtable) sponsored a workshop during the STAIR XIII conference in Washington, DC on March 27 to 28, 2025, to develop consensus recommendations, particularly regarding research priorities and design elements for trials of reperfusion therapies. This forum brought together stroke neurologists, neuroradiologists, neuroimaging research scientists, membe…

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