Peer-Reviewed Publication
Sci Adv2025;11(46):eadz2251.November 14, 2025Journal Article
Small things matter: Lack of extraislet β cells in type 1 diabetes.
Kathryn Murrall1, Teifion Luckett1, Christiana Lekka1, Christine S Flaxman1, Rebecca Wyatt1,2, Pouria Akhbari1, Irina Kusmartseva3, Stephanie L Hunter1, Pia Leete1, Isabel Burn1,4, Elena Osokina1, , James A M Shaw5, Noel G Morgan1, Sarah J Richardson1
1Islet Biology Exeter (IBEx), Exeter Centre of Excellence for Diabetes Research (EXCEED), Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, UK.
2Indica Labs, Albuquerque, NM 87114, USA.
3Department of Pathology, Immunology, and Laboratory Medicine, Diabetes Institute, College of Medicine, University of Florida, Gainesville, FL 32611, USA.
4Cambridge Institute for Therapeutic Immunology and Infectious Disease (CITIID), University of Cambridge, Cambridge, UK.
5Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Abstract
Recent three-dimensional (3D) analyses reported an abundance of small β cell-rich endocrine objects (EOs) in the human pancreas. Here, we used archival, immunolabeled 2D pancreas sections to assess morphological EO parameters in donors with or without type 1 diabetes (T1D), varying in age and disease duration. We confirm that abundant small, insulin-positive EOs are present in donors without diabe…
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