Multifocal optical coherence tomography of the mouse eye to image the vitreoretinal vasculature in full depth.

Simon Brais-Brunet^1,2, Raphaël Maltais-Tariant³, Caroline Boudoux^2,3,4, Mathieu Dehaes^1,2,5

¹Université de Montréal, Institute of Biomedical Engineering, Montreal, Quebec, Canada.

²Centre de Recherche Azrieli du CHU Sainte-Justine, Montreal, Quebec, Canada.

³Polytechnique Montréal, Department of Engineering Physics, Montreal, Quebec, Canada.

⁴Castor Optics, Saint-Laurent, Quebec, Canada.

⁵Université de Montréal, Department of Radiology, Radio-Oncology and Nuclear Medicine, Montreal, Quebec, Canada.

PubMed PMC DOI PDF

Abstract

SIGNIFICANCE: In vivo optical coherence tomography (OCT) of the mouse vitreoretinal vasculature in full depth is technically challenging. Conventional OCT techniques employ axial confocal gating, which induces signal drop-off and limits spatial resolution outside the Rayleigh range. AIM: Our aim is to develop a multifocal OCT imaging approach using a tunable lens and a registration method that al…

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