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Peer-Reviewed Publication
JAMA Netw Open2025;8(10):e2540065.October 1, 2025Journal Article

Message-Based vs Video-Based Psychotherapy for Depression: A Randomized Clinical Trial.

Michael D Pullmann1, Julien Rouvere1, Patrick J Raue1, Isabell R Griffith Fillipo1, Brittany A Mosser1, Patrick J Heagerty2, Nicole Fridling-Cook3, Aarthi Padmanabhan3, Thomas D Hull3, Patricia A Areán1
1Department of Psychiatry and Behavioral Sciences, School of Medicine, University of Washington, Seattle.
2Department of Biostatistics, School of Public Health, University of Washington, Seattle.
3Talkspace Inc, New York, New York.

Abstract

IMPORTANCE: There is a need to determine the relative effect of message-based psychotherapy (MBP), an asynchronous approach that uses emails, texts, or voice or video messages to permit therapeutic exchanges, compared with video-based psychotherapy (VBP) and whether a combination of modalities would result in better outcomes for those who do not respond to either treatment alone. OBJECTIVES: To c…

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