Peer-Reviewed Publication
JACC Cardiovasc Interv2026;19(2):145-156.January 26, 2026Journal Article
AI-Enabled ECG Analysis Improves Diagnostic Accuracy and Reduces False STEMI Activations: A Multicenter U.S. Registry.
Robert Herman1, Bryn E Mumma2, Jake D Hoyne3, Benjamin L Cooper4, Nils P Johnson5, Timea Kisova6, Anthony Demolder7, Adam Rafajdus6, Andrej Iring6, Timotej Palus6, Marta Belmonte8, Emanuele Barbato8, Suzanne J Baron9, Robert Hatala10, Stephen W Smith11, H Pendell Meyers12, Scott W Sharkey13, Jozef Bartunek14, Timothy D Henry15
1Cardiovascular Center Aalst, AZORG Hospital, Aalst, Belgium; Powerful Medical, Bratislava, Slovakia. Electronic address: robi.herman@gmail.com.
2Department of Emergency Medicine, University of California, Davis, Davis, California, USA.
3Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
4Department of Emergency Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, and Memorial Hermann Hospital, Texas Medical Center, Houston, Texas, USA.
5Division of Cardiology, Department of Medicine, Weatherhead PET Imaging Center, McGovern Medical School, University of Texas Health Science Center, and Memorial Hermann Hospital, Houston, Texas, USA.
6Powerful Medical, Bratislava, Slovakia.
7Cardiovascular Center Aalst, AZORG Hospital, Aalst, Belgium; Powerful Medical, Bratislava, Slovakia.
8Department of Cardiology, Sapienza University of Rome, Rome, Italy.
9Department of Cardiology, Massachusetts General Hospital and Baim Institute for Clinical Research, Boston, Massachusetts, USA.
10Department of Arrhythmia and Pacing, National Institute of Cardiovascular Diseases, Bratislava, Slovakia.
11Department of Emergency Medicine, Hennepin County Medical Center and University of Minnesota, Minneapolis, Minnesota, USA.
12Department of Emergency Medicine, Carolinas Medical Center and Wake Forest University School of Medicine, Charlotte, North Carolina, USA.
13Minneapolis Heart Institute, Abbott Northwestern Hospital, Minneapolis, Minnesota, USA.
14Cardiovascular Center Aalst, AZORG Hospital, Aalst, Belgium.
15Carl and Edyth Lindner Center for Research and Education, The Christ Hospital, Cincinnati, Ohio, USA. Electronic address: tim.henry@thechristhospital.com.
Abstract
BACKGROUND: Timely reperfusion is critical in reducing mortality in ST-segment elevation myocardial infarction (STEMI). Although electrocardiography-guided cardiac catheterization laboratory (CCL) activation on the basis of first medical contact recognition improves system-level response, diagnostic uncertainty, particularly in atypical presentations, contributes to false positive activations (FPA…
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