Peer-Reviewed Publication
Alzheimers Dement2025;21(10):e70758.October 1, 2025Journal Article
Contactless longitudinal monitoring in the home characterizes aging and Alzheimer's disease-related night-time behavior and physiology.
Eyal Soreq1,2, Magdalena A Kolanko1,2, , Kiran K G Ravindran1,3, Ciro Della Monica1,3, Victoria Revell1,3, Sarah Daniels1,2, Anna Joffe1,2, Helen Lai1,2, Mara Golemme1,2, Martina Del Giovane1, Chloe Walsh1,2,4, David Wingfield1,2, Ramin Nilforooshan1,4, Marie-Ange Stefanos5,6, Benjamin Vittrant5, Paul de Villèle5, Derk-Jan Dijk1,3, David J Sharp1,2
1UK Dementia Research Institute Care Research and Technology Centre, Imperial College London Sir Michael Uren Hub, White City Campus, London, and the University of Surrey, Guildford, UK.
2Department of Brain Sciences, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, UK.
3Surrey Sleep Research Centre, School of Biosciences, University of Surrey, Guildford, UK.
4Surrey and Borders Partnership NHS Foundation Trust, Leatherhead, UK.
5Withings Inc., Issy-les-Moulineaux, France.
6Université Paris Cité, NeuroDiderot, Inserm, Université Paris Cité, Paris, France.
Abstract
INTRODUCTION: Disturbed sleep patterns are common in dementia but have not been objectively quantified over long periods.
METHODS: We compared a cohort of 83 Alzheimer's disease (AD) patients to 13,588 individuals from the general population. Sleep patterns, heart rate, and breathing rate data were acquired using a zero-burden contactless, under-mattress pressure sensor. Data reduction and explai…
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