Peer-Reviewed Publication
Crit Care2025;29(1):432.October 14, 2025Journal Article
Circulating endothelial signatures correlate with worse outcomes in COVID-19, respiratory failure and ARDS.
Ana C Costa Monteiro1, Harry Pickering2, Aartik Sarma3, Clove S Taylor2, Meagan M Jenkins2, Fei-Man Hsu2, Brian Nadel4, Ofer Levy5,6,7, Lindsey R Baden6, Esther Melamed8, Lauren I R Ehrlich8, Grace A McComsey9, Rafick P Sekaly10, Charles B Cairns11, Elias K Haddad11, Albert C Shaw12, David A Hafler12, Ruth R Montgomery12, David B Corry13, Farrah Kheradmand13, Mark A Atkinson14, Scott C Brakenridge15, Nelson I Agudelo Higuita16, Jordan P Metcalf16, Catherine L Hough17, William B Messer17, Bali Pulendran18, Kari C Nadeau19, Mark M Davis18, Linda N Geng18, Ana Fernandez-Sesma20, Viviana Simon20, Florian Krammer20, Monica Kraft20, Chris Bime21, Carolyn S Calfee3, David J Erle3, Steve Bosinger10, Walter Eckalbar3, Holden Maecker18, Adeeb Rahman22, Leying Guan12, Bjoern Peters23, Steven H Kleinstein12, Alison D Augustine24, Joann Diray-Arce6, Patrice M Becker24, Nadine Rouphael10, , , Michael Agus5,6, Hrishikesh Kulkarni2, Joanna M Schaenmann2, Ramin Salehi-Rad2,25, Michael A Matthay3, Elaine F Reed2, Anil Sapru26
1University of California School of Medicine- Los Angeles, Los Angeles, CA, USA. Acostamonteiro@mednet.ucla.edu.
2University of California School of Medicine- Los Angeles, Los Angeles, CA, USA.
3University of California- San Francisco, San Francisco, CA, USA.
4University of Southern California, Los Angeles, CA, USA.
5Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.
6Harvard Medical School, Boston, MA, USA.
7Broad Institute of MIT & Harvard, Boston, MA, USA.
8University of Texas- Austin, Austin, TX, USA.
9Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH, USA.
10Emory University, Atlanta, GA, USA.
11Drexel University College of Medicine, Philadelphia, PA, USA.
12Yale University School of Medicine, New Haven, CT, USA.
13Baylor School of Medicine, Houston, TX, USA.
14University of Florida College of Medicine, Gainesville, FL, USA.
15University of Washington School of Medicine, Seattle, WA, USA.
16Oklahoma University Health Sciences Center, Oklahoma City, OK, USA.
17Oregon Health & Science University, Portland, OR, USA.
18Stanford University School of Medicine, Stanford, CA, USA.
19Harvard T. H. Chan School of Public Health, Boston, MA, USA.
20Icahn School of Medicine at Mount Sinai, New York, NY, USA.
21University of Arizona College of Medicine, Phoenix, AZ, USA.
22Immunai, New York, NY, USA.
23La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA.
24National Institute of Allergy and Infectious Disease, Bethesda, USA.
25Veteran Affairs- Greater Los Angeles, Los Angeles, CA, USA.
26University of California School of Medicine- Los Angeles, Los Angeles, CA, USA. ASapru@mednet.ucla.edu.
Abstract
BACKGROUND: Elevated circulating endothelial cells (CECs), released from monolayers after insult, have been implicated in worse outcomes in ARDS and COVID-19, however there is no consensus proteomic phenotype that define CECs. We queried whether a transcriptomic approach would alternatively support the presence of endothelial cells in circulation and correlate with worsening respiratory failure.…
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