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Lancet Oncol2025;26(11):1417-1431.November 1, 2025Journal Article

Clinical potential of whole-genome data linked to mortality statistics in patients with breast cancer in the UK: a retrospective analysis.

Daniella Black1, Helen Ruth Davies2, Gene Ching Chiek Koh3, Lucia Chmelova1, Marko Cubric4, Georgia Chalivelaki Chan4, Andrea Degasperi1, Jan Czarnecki1, Ping Jing Toong1, Yasin Memari1, James Whitworth5, Salome Jingchen Zhao1, Yogesh Kumar1, Shadi Basyuni1, Giuseppe Rinaldi1, Scott Shooter1, Vladyslav Dembrovskyi6, Rosie Davies6, Maria Chatzou Dunford6, Ellen Copson7, Carlo Palmieri8, Åke Borg9, John Ambrose4, Catey Bunce10, Alona Sosinsky4, Prabhu Arumugam4, Matthew Arthur Brown4, Johan Staaf9, Nicholas Turner10, Serena Nik-Zainal11
1Department of Genomic Medicine, University of Cambridge, Cambridge, UK; Early Cancer Institute, Department of Oncology, University of Cambridge, Cambridge, UK.
2Department of Genomic Medicine, University of Cambridge, Cambridge, UK; Early Cancer Institute, Department of Oncology, University of Cambridge, Cambridge, UK; Lifebit Biotech, London, UK.
3Department of Genomic Medicine, University of Cambridge, Cambridge, UK; Early Cancer Institute, Department of Oncology, University of Cambridge, Cambridge, UK; Sir Jeffrey Cheah Sunway Medical School, Faculty of Medical and Life Sciences, Sunway University, Sunway City, Malaysia.
4Genomics England, London, UK.
5Department of Genomic Medicine, University of Cambridge, Cambridge, UK.
6Lifebit Biotech, London, UK.
7Cancer Sciences Academic Unit, University of Southampton, Southampton, UK.
8The Clatterbridge Cancer Centre, Wirral, UK; Department of Molecular and Clinical Cancer, Medicine, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
9Division of Oncology & Pathology, Department of Clinical Sciences, Lund University, Lund, Sweden.
10Breast Unit, Royal Marsden Hospital and Institute of Cancer Research, London, UK; NIHR Institute of Cancer Research BRC, London, UK.
11Department of Genomic Medicine, University of Cambridge, Cambridge, UK; Early Cancer Institute, Department of Oncology, University of Cambridge, Cambridge, UK. Electronic address: sn206@cam.ac.uk.
PubMed DOI

Abstract

BACKGROUND: Breast cancer is the most frequently diagnosed cancer in women. Survival is generally considered favourable, yet some patients remain at risk of early death. We aimed to assess whether comprehensive whole-genome sequencing (WGS) linked to mortality data could add prognostic value to existing clinical measures and identify patients who might respond to targeted therapeutics. METHODS: I…

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