Quantitative temporal analysis of pancreatic islet T lymphocyte and macrophage infiltration heralded by serum IgE in congenic BioBreeding (BB) Gimap5-/- rats at risk for insulitis and acute onset diabetes.

Josefine Jönsson¹, Linda Faxius², Jeanette Tångrot³, Krysten Vance⁴, Stephanie Jerman⁴, Doug Bowman⁴, Marika Bogdani⁵, Peter Ericsson², Rasmus Bennet², Anita Ramelius², Åke Lernmark²

¹Department of Clinical Sciences, Skåne University Hospital, Lund University CRC, 214 28, Malmö, Sweden. josefine.jonsson@med.lu.se.

²Department of Clinical Sciences, Skåne University Hospital, Lund University CRC, 214 28, Malmö, Sweden.

³Department of Molecular Biology, National Bioinformatics Infrastructure Sweden (NBIS), Umeå University, 901 87, Umeå, Sweden.

⁴Indica Labs, 8700 Education Pl NW, Bldg. b, Albuquerque, NM, 87114, USA.

⁵University of Washington, Seattle, WA, USA.

PubMed PMC DOI PDF

Abstract

OBJECTIVE AND DESIGN: The objective was to determine the association between serum IgE levels and the infiltration order of T lymphocytes and macrophages in pancreatic islets in relation to the loss of insulin and glucagon cells in presymptomatic congenic BB Gimap5-DP (Diabetes Prone) rats. MATERIAL: Congenic prediabetes BB Gimap5-DP and control Gimap5-DR (Diabetes Resistant) rats were followed e…

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