Convergence of nanotechnology and CRISPR-based diagnostics.

Midori Johnston¹, Schan Dissanayake-Perera^2,3, James J Collins^4,5,6, Molly M Stevens^7,8, Can Dincer^9,10

¹IMTEK-Department of Microsystems Engineering, University of Freiburg, Freiburg, Germany.

²Department of Materials, Department of Bioengineering and Institute of Biomedical Engineering, Imperial College London, London, UK.

³Department of Physiology, Anatomy and Genetics, Department of Engineering Science, Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.

⁴Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.

⁵Institute of Medical Engineering & Science and Department of Biological Engineering, MIT, Cambridge, MA, USA.

⁶Broad Institute of MIT and Harvard, Cambridge, MA, USA.

⁷Department of Materials, Department of Bioengineering and Institute of Biomedical Engineering, Imperial College London, London, UK. molly.stevens@dpag.ox.ac.uk.

⁸Department of Physiology, Anatomy and Genetics, Department of Engineering Science, Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK. molly.stevens@dpag.ox.ac.uk.

⁹IMTEK-Department of Microsystems Engineering, University of Freiburg, Freiburg, Germany. can.dincer@tum.de.

¹⁰Institute of Biomedical Engineering-MIBE, Department of Electrical Engineering, TUM School of Computation, Information and Technology, Technical University of Munich, Munich, Germany. can.dincer@tum.de.

PubMed DOI

Abstract

In addition to its broad application in genome engineering and therapeutics, clustered regularly interspaced short palindromic repeats (CRISPR) technology provides field-deployable methods for the highly sensitive and selective detection of nucleic acids. From a diagnostic perspective, CRISPR-based assays hold clear clinical potential for identifying a range of both infectious and non-communicable…

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