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Peer-Reviewed Publication
EJNMMI Phys2025;12(1):85.September 29, 2025Journal Article

Large scale comparison of maximum likelihood scatter scaling and tail-fitted scatter scaling in LAFOV PET/CT.

Nanna Overbeck1, Søren Holm2, Mohammadreza Teimoorisichani3, Maurizio Conti3, Thomas Lund Andersen2,4, Flemming Littrup Andersen2,4
1Department of Clinical Physiology and Nuclear Medicine, Rigshospitalet-Copenhagen University Hospital, Copenhagen, Denmark. nanna.overbeck.petersen.01@regionh.dk.
2Department of Clinical Physiology and Nuclear Medicine, Rigshospitalet-Copenhagen University Hospital, Copenhagen, Denmark.
3Siemens Medical Solutions Inc., Knoxville, TN, USA.
4Departement of Clinical Medicine, Copenhagen University, Copenhagen, Denmark.

Abstract

BACKGROUND: Scatter scaling during the reconstruction of Positron Emission Tomography (PET) data is a crucial element for obtaining clinically applicable images with accurate quantification and high image quality. The current clinical standard for scatter scaling is fitting the tail regions of the single scatter simulation (SSS) estimate, which is termed Tail-Fitted Scatter Scaling (TFSS). This st…

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