Peer-Reviewed Publication
Sci Rep2025;15(1):32881.September 25, 2025Journal Article

Impact of AI-quantified fluid dynamics on visual outcomes over 5 years in patients with treatment-naïve nAMD from the FRB! registry.

Philipp Fuchs1, Ursula Schmidt-Erfurth2,3, Leonard M Coulibaly1, Hrvoje Bogunovic1, Oliver Leingang1, Anastasiia Gruber1,4, Florian Frommlet4, Virginia Mares1,5, Daniel Barthelmes6, Gregor S Reiter1
1Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria.
2Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria. Ursula.schmidt-erfurth@meduniwien.ac.at.
3, Währinger Gürtel 18-20, Vienna, 1090, Austria. Ursula.schmidt-erfurth@meduniwien.ac.at.
4Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, Vienna, Austria.
5Department of Ophthalmology, Federal University of Minas Gerais, Belo Horizonte, Brazil.
6Department of Ophthalmology, University Hospital Zurich, Zurich, Switzerland.

Abstract

To investigate the impact of retinal fluid dynamics on visual outcomes in patients with treatment-naïve neovascular age-related macular degeneration (nAMD) treated in the real world over 5 years using approved AI-based fluid monitoring. Real-world data comprising OCT scans and electronic medical records from 148 patients (187 eyes) were extracted from the Fight Retinal Blindness! (FRB! ) Zürich da…

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