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Peer-Reviewed Publication
Pract Lab Med2025;47e00502.December 1, 2025Journal Article

Analytical validation of a scrape-free multitarget stool RNA test for colorectal cancer screening.

Erica K Barnell1,2, Kimberly Kruse2, Elizabeth M Wurtzler2, Maya Crowder Scott2, Andrew R Barnell2, Eric J Duncavage3
1Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
2Geneoscopy Inc., Saint Louis, MO, USA.
3Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA.
PubMed PMC DOI PDF

Abstract

BACKGROUND & AIMS: Traditional stool-based colorectal cancer (CRC) screening tests require patients to collect and swab their own stool, which can reduce adherence due to aversion and introduce variability from user error. A novel multitarget stool RNA test (mt-sRNA, ColoSense) eliminates the need for scraping or swabbing stool. Instead, patients merely deposit and ship a sample to the lab. Once r…

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