Health AI Central
Peer-Reviewed Publication
J Alzheimers Dis2025;108(2):844-861.November 1, 2025Journal Article

Easy-to-use and easy-to-interpret quality control of 3D gradient echo T1-weighted MR acquisition sequences for improved test-retest stability of MRI-based hippocampus volumetry.

Ralph Buchert1, Per Suppa2, Babak A Ardekani3, Fuensanta Bellvís Bataller4, Pierrick Bourgeat5, Pierrick Coupé6, Robert Dahnke7,8,9, Gabriel A Devenyi10, Simon Fristed Eskildsen11, Clara Fischer12, Jose Vincente Manjón Herrera13, Christian Ledig14, Andreas Lemke15, Bénédicte Maréchal16, Roland Opfer17, Diana M Sima18, Lothar Spies17, Aziz M Ulug19, Hans-Jürgen Huppertz20
1Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
2Olympus Winter & Ibe GmbH, Hamburg, Germany.
3Center for Brain Imaging and Neuromodulation, The Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA.
4Quantitative Imaging Biomarkers in Medicine (Quibim), Valencia, Spain.
5Australian e-Health Research Centre, CSIRO Health and Biosecurity, Brisbane, Australia.
6LaBRI - UMR 5800, University of Bordeaux, Talence, France.
7Structural Brain Mapping Group, Department of Neurology, Jena University Hospital, Jena, Germany.
8Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.
9German Center for Mental Health (DZPG), Jena, Germany.
10Department of Psychiatry, Cerebral Imaging Center, Douglas Mental Health University Institute, McGill University, Montréal, Quebec, Canada.
11Department of Clinical Medicine, Center of Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark.
12CATI, US52-UAR2031, CEA, ICM, SU, CNRS, INSERM, APHP, Ile de France, Paris, France.
13Applied Physics Department, MIA Lab, ITACA Institute, Universidad Politécnica de Valencia, Valencia, Spain.
14xAILab Bamberg, University of Bamberg, Bamberg, Germany.
15Mediaire GmbH, Berlin, Germany.
16Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland.
17Jung Diagnostics GmbH, Hamburg, Germany.
18Icometrix, Leuven, Belgium.
19Cortechs Labs, Inc., San Diego, CA, USA.
20Swiss Epilepsy Center, Klinik Lengg, Zurich, Switzerland.
PubMed PMC DOI PDF

Abstract

BackgroundMRI-based hippocampus volume (HV) is widely used as neurodegeneration marker in Alzheimer's disease.ObjectiveAn easy-to-use and easy-to-interpret method to categorize T1-weighted MR sequences with respect to test-retest stability of hippocampus volumetry based on general image quality metrics (IQM).MethodsThe study included 446 3D T1-weighted MRI scans of one healthy middle-aged man obta…

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