Peer-Reviewed Publication
Front Artif Intell2025;81623393.January 1, 2025Journal Article

Enhancing prediction of primary site recurrence in head and neck cancer using radiomics and uncertainty estimation.

Yu Hu1, Kimberly Taing1, Jing Wang1, David Sher1, Michael Dohopolski1
1Medical Artificial Intelligence and Automation Lab, Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, TX, United States.

Abstract

INTRODUCTION: Head and neck squamous cell carcinomas (HNSCC) present a significant clinical challenge due to high recurrence rates despite advances in radiation and chemotherapy. Early detection of recurrence is critical for optimizing treatment outcomes and improving patient survival. METHODS: We developed two artificial intelligence (AI) pipelines-(1) machine learning models trained on radiomic…

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