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Peer-Reviewed Publication
Prostate Cancer Prostatic Dis2026;29(2):346-352.June 1, 2026Journal Article

Using patient-reported outcomes from the PROCLAIM trial to assess the impact of universal germline genetic testing for prostate cancer patients.

Neal D Shore1, Christopher M Pieczonka2, Sean Heron3, Mukaram Gazi4, David J Cahn5, Laurence H Belkoff6, Aaron D Berger7, Brian Mazzarella8, Joseph Veys9, David Morris10, Richard Bevan-Thomas11, Alexander Engelman12, Paul Dato13, David R Wise14, Mary Kay Hardwick15, Kerry W Aradhya15, Brandie Heald15, Robert L Nussbaum15,16, Kathryn E Hatchell15, Brianna Bucknor17, Edward D Esplin15, Sarah M Nielsen17
1Carolina Urologic Research Center, Myrtle Beach, SC, USA. nshore@auclinics.com.
2Associated Medical Professionals of NY, Syracuse, NY, USA.
3Advanced Urology Institute, St. Petersburg, FL, USA.
4University Urology Associates of New Jersey, Hamilton, NJ, USA.
5Colorado Urology, Lakewood, CO, USA.
6Midlantic Urology, Bala Cynwyd, PA, USA.
7Associated Urological Specialists, Chicago Ridge, IL, USA.
8Urology Austin, Austin, TX, USA.
9North Georgia Urology Center, Dalton, GA, USA.
10Urology Associates P.C., Nashville, TN, USA.
11Urology Partners, Arlington, TX, USA.
12Florida Urology Partners, Cancer Center of South Tampa, Tampa, FL, USA.
13Genesis Healthcare Partners, San Diego, CA, USA.
14Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA.
15Former employee of Invitae Corp., San Francisco, CA, USA.
16Volunteer Faculty, University of California San Francisco, San Francisco, CA, USA.
17Labcorp (formerly Invitae Corp.), San Francisco, CA, USA.
PubMed PMC DOI PDF

Abstract

BACKGROUND: Although germline genetic testing can inform medical management for patients with prostate cancer (PCa), data are limited regarding patient-reported outcomes (PROs) after germline genetic testing for PCa. Recall and comprehension of germline genetic testing results, uptake of post-test clinical recommendations, and psychological impact of germline genetic testing among patients with PC…

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