Health AI Central
Peer-Reviewed Publication
J Gen Intern Med2025;40(16):4033-4039.December 1, 2025Journal Article

Entropy in Clinical Decision-Making: A Narrative Review Through the Lens of Decision Theory.

Cory Rohlfsen1, Kevin Shannon2, Andrew S Parsons3
1Department of Medicine, University of Nebraska Medical Center, Omaha, USA. cory.rohlfsen@unmc.edu.
2University of Virginia School of Medicine, Charlottesville, USA.
3Department of Medicine, University of Virginia School of Medicine, Charlottesville, USA.
PubMed PMC DOI PDF

Abstract

Navigating uncertainty is fundamental to sound clinical decision-making. With the advent of artificial intelligence, mathematical approximations of disease states-expressed as entropy-offer a novel approach to quantify and communicate uncertainty. Although entropy is well established in fields like physics and computer science, its technical complexity has delayed its routine adoption in clinical…

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