Digital biomarkers as predictors of brain injury in neonatal encephalopathy.

Nahla Zaghloul¹, Neel Kamal Singh¹, Weihuang Xu², Kaitlyn Lagnese¹, Livia Sura¹, Juan Carlos Roig¹, Mehmet Albayram³, Dhanashree Rajderkar³, James L Wynn¹, Alina Zare², Michael D Weiss¹

¹Division of Neonatology, Department of Pediatrics, University of Florida, Gainesville, FL, United States.

²Department of Electrical and Computer Engineering, University of Florida, Gainesville, FL, United States.

³Department of Radiology, University of Florida, Gainesville, FL, United States.

PubMed PMC DOI PDF

Abstract

BACKGROUND: Neonatal encephalopathy (NE) is a significant cause of neurodevelopmental impairment, with therapeutic hypothermia (TH) being the current standard of care for mitigating brain injury in affected neonates. Despite advances, there is a critical need for early, reliable biomarkers that can predict brain injury severity and long-term outcomes, particularly during the 72-h hypothermia windo…

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