Long-Term Feasibility and Outcomes of a Digital Health Program to Improve Liver Fat and Cardiometabolic Markers in Individuals With Nonalcoholic Fatty Liver Disease: Prospective Single-Arm Feasibility Study.

Sigridur Björnsdottir^1,2, Hildigunnur Ulfsdottir³, Elias Freyr Gudmundsson³, Bartosz Dobies^3,4, Kolbrun Sveinsdottir³, Ari Pall Isberg³, Gudlaug E A Magnusdottir³, Thrudur Gunnarsdottir³, Tekla Karlsdottir³, Gudlaug Bjornsdottir^5,6, Sigurdur Sigurdsson^5,6, Saemundur Oddsson³, Vilmundur Gudnason^5,6

¹Department of Molecular Medicine and Surgery, Karolinska University Hospital, Eugeniavägen 3, Solna, Stockholm, 171 77, Sweden, 354 8217107.

²Heilsuklasinn, Reykjavik, Iceland.

³Clinical Office, Sidekick Health, Vallakor 4, Kopavogur, 200, Iceland.

⁴Doctoral School of Medical and Health Sciences, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland.

⁵Icelandic Heart Association, Kopavogur, Iceland.

⁶School of Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik, Iceland.

PubMed PMC DOI PDF

Abstract

BACKGROUND: A 12-week digital health program for nonalcoholic fatty liver disease (NAFLD) previously showed feasibility in engagement, program retention, and clinical outcomes. This study investigates whether improvements in cardiometabolic risk factors achieved during a 12-week active program were sustained over a subsequent 6-month follow-up period. OBJECTIVE: The primary objective of this anal…

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Mentioned Companies

Sidekick Health
affiliation

MeSH Terms

Humans0Non-alcoholic Fatty Liver Disease*Female0Male0Middle Aged0Feasibility Studies0Prospective Studies0Liver*Biomarkers0Diabetes Mellitus, Type 20Magnetic Resonance Imaging0Metabolic Syndrome0Follow-Up Studies0Digital Health0

Keywords

BMIMAFLDMASLDNAFLDacceptabilitybody compositioncardiologycardiometaboliccardiometabolic healthcardiovascularchroniccoachcoachingdiabetesdiabeticdietdietarydigital healthdigital health programdigital therapeuticsexercisefatfeasibilityhepaticlifestylelivermetabolic syndromenonalcoholic fatty liver diseasenutritionnutritionalpatient educationphysical activitytype 2 diabetesweight

Article Info

PMID: 40939135
PMCID: PMC12431163
DOI: 10.2196/72074
Received: February 17, 2025
Accepted: August 5, 2025

How to Cite

Björnsdottir S et al. Long-Term Feasibility and Outcomes of a Digital Health Program to Improve Liver Fat and Cardiometabolic Markers in Individuals With Nonalcoholic Fatty Liver Disease: Prospective Single-Arm Feasibility Study. JMIR Cardio2025;9e72074. doi:10.2196/72074

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