Health AI Central
Peer-Reviewed Publication
Res Sq2025August 25, 2025Journal Article

A Crowdsourced Megastudy of 12 Digital Single-Session Interventions for Depression in American Adults.

Benjamin Kaveladze1, Jan Voelkel2, Michael Stagnaro3, Mingjing Huang4, Amanda Smock4, Erin Sullivan5, Yao Xu6, Madison McCall7, Juan Pablo Zapata4, Syed Ishtiaque8, Ananya Bhattacharjee8, Iva Georgieva9, Rosa Hernandez-Ramos10, Kenneth Huber11, Julia Jennings12, Arianna Kirk13, Rachel Kornfield4, Robert Knowles14, Monika Lind10, Michelle Liu15, Michael Liut16, Alex Mariakakis8, Ali Mattu17, Adam McGuire18, Jonah Meyerhoff19, Alissa Mrazek20, Michael Mrazek20, David Mohr4, Robert Morris14, Christopher Mosunic11, Hana Nip10, Allen Olson-Urtecho21, Jessa Podell20, Dustyn Ransom20, Shireen Rizvi22, Matthew Southward23, Sarah Elizabeth Stoeckl10, Madison Taylor10, Amy Texter24, Angelique Trotter20, Calvin Tower20, Joseph Williams8, Elijah Woodson20, Katherine Wislocki10, John Protzko5, Lorenzo Lorenzo-Luaces25, Stephen Schueller26, Matthew Nock27, Jessica Schleider4
1University of California, Irvine, USA.
2Cornell University.
3Yale University.
4Northwestern University.
5Central Connecticut State University.
6Stanford University.
7University of North Carolina at Chapel Hill.
8University of Toronto.
9Bulgarian Academy of Sciences.
10University of California, Irvine.
11Calm Health.
12University of Texas at Austin.
13Visionari Media.
14Koko.
15Loyola University Chicago.
16University of Toronto Mississauga.
17Mind Stuff LLC.
18The University of Texas at Tyler.
19Northwestern University Feinberg School of Medicine.
20The University of Texas at Austin.
21Studio Bahia.
22Albert Einstein College of Medicine.
23The Ohio State University.
24University of Colorado Boulder.
25Indiana University Bloomington.
26University of California Irvine.
27Harvard University.
PubMed PMC DOI PDF

Abstract

Digital self-guided single-session interventions (SSIs) provide a structured psychological intervention within one interaction. We crowdsourced 66 diverse 10-minute SSIs for depression and selected 11 for testing in a pre-registered "megastudy" (ClinicalTrials.gov ID: NCT06856668). American adults (N = 7,505) experiencing elevated depressive symptoms were recruited online and randomly assigned to…

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