IMX-SEV-3b mRNA classifier predicts ICU care and 30-day mortality in febrile neutropenic emergency department patients.

David A Meguerdichian¹, Guruprasad Jambaulikar², Oliver Liesenfeld³, Shailee Rasania⁴, Joshua Joseph⁵, James Wacker⁶, Christopher W Baugh⁷

¹Department of Emergency Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, United States of America. Electronic address: dmeguerdichian@bwh.harvard.edu.

²Department of Emergency Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, United States of America. Electronic address: gjambaulikar@bwh.harvard.edu.

³Inflammatix, 540 Oakmead Pkwy, Sunnyvale, CA 94085;, United States of America. Electronic address: oliesenfeld@inflammatix.com.

⁴Inflammatix, 540 Oakmead Pkwy, Sunnyvale, CA 94085;, United States of America. Electronic address: srasania@inflammatix.com.

⁵Department of Emergency Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, United States of America. Electronic address: jjoseph24@mgb.org.

⁶Inflammatix, 540 Oakmead Pkwy, Sunnyvale, CA 94085;, United States of America. Electronic address: jwacker@inflammatix.com.

⁷Department of Emergency Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, United States of America. Electronic address: cbaugh@bwh.harvard.edu.

PubMed DOI

Abstract

BACKGROUND: Chemotherapy-associated febrile neutropenia (FN) is a common, life-threatening oncologic emergency. Scores to identify low-risk patients eligible for outpatient treatment, like the Multinational Association for Supportive Care in Cancer (MASCC), Clinical Index of Stable Febrile Neutropenia (CISNE), and quick Sepsis Related Organ Failure Assessment (qSOFA) scores, are infrequently used.…

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