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Peer-Reviewed Publication
J Imaging Inform Med2026;39(3):2095-2109.June 1, 2026Journal Article

Robust Quantification of Affected Brain Volume from Computed Tomography Perfusion: A Hybrid Approach Combining Deep Learning and Singular Value Decomposition.

Gi-Youn Kim1, Hyeon Sik Yang1, Jundong Hwang1, Kijeong Lee1, Jin Wook Choi2, Woo Sang Jung2, Regina Eun Young Kim1, Donghyeon Kim1, Minho Lee3
1Research Institute, Neurophet Inc., 12F, 124, Teheran-ro, Gangnam-gu, Seoul, Republic of Korea.
2Department of Radiology, Ajou University School of Medicine, Suwon, Republic of Korea.
3Research Institute, Neurophet Inc., 12F, 124, Teheran-ro, Gangnam-gu, Seoul, Republic of Korea. minho.lee@neurophet.com.

Abstract

Volumetric estimation of affected brain volumes using computed tomography perfusion (CTP) is crucial in the management of acute ischemic stroke (AIS) and relies on commercial software, which has limitations such as variations in results due to image quality. To predict affected brain volume accurately and robustly, we propose a hybrid approach that integrates singular value decomposition (SVD), de…

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