Peer-Reviewed Publication
Comput Med Imaging Graph2025;125102630.October 1, 2025Journal Article

Inference time correction based on confidence and uncertainty for improved deep-learning model performance and explainability in medical image classification.

Joel Jeffrey1, Ashwin RajKumar1, Sudhanshu Pandey1, Lokesh Bathala2, Phaneendra K Yalavarthy3
1Department of Computational and Data Sciences, Indian Institute of Science, Bangalore, Karnataka, 560012, India.
2Aster-CMI Hospital, Bangalore, Karnataka, 560092, India.
3Department of Computational and Data Sciences, Indian Institute of Science, Bangalore, Karnataka, 560012, India. Electronic address: yalavarthy@iisc.ac.in.

Abstract

The major challenge faced by artificial intelligence (AI) models for medical image analysis is the class imbalance of training data and limited explainability. This study introduces a Confidence and Entropy-based Uncertainty Thresholding Algorithm (CEbUTAl), which is a novel post-processing method, designed to enhance both model performance and explainability. CEbUTAl modifies model predictions du…

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