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Nat Commun2025;16(1):7848.August 22, 2025Journal Article

Multivariate protein landscape of host response in hospitalised patients with suspected infection in the emergency department.

Pratik Sinha1, Alexandra B Spicer2, Sivasubramanium Bhavani3, Carlos López-Espina4, Gregory L Watson4, Akhil Bhargava4, Lee Schmalz4, Shah Khan4, Matthew D Sims5,6, Ashok V Palagiri7, Alon Dagan8, Karthik V Iyer9, Matthew J Crisp10, Carmen DeMarco5, Alexandra Halalau5, Nicholas Maddens5, Niko Kurtzman3, Deesha Sarma8, Falgun Gosai10, Anwaruddin Syed10, Saleem Azad9, Aimee Espinosa5, Francisco Davila5, Hugo Davila5, Neil Shadbeh Evans11, Scott Smith5, Bobby Reddy4, Philip A Verhoef12,13, Matthew M Churpek2
1Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA. p.sinha@wustl.edu.
2Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.
3Department of Medicine, Emory University, Atlanta, GA, USA.
4Prenosis Inc, Chicago, IL, USA.
5Department of Medicine, Corewell Health William Beaumont University Hospital, Royal Oak, MI, USA.
6Departments of Internal Medicine and Foundational Medical Studies, Oakland University William Beaumont School of Medicine, Rochester, MI, USA.
7Mercy Hospital, St. Louis, MO, USA.
8Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
9Mercy Hospital Jefferson, Festus, MO, USA.
10OSF Saint Francis Medical Center, Peoria, IL, USA.
11Department of Medicine, UC Davis Medical Center, Sacramento, CA, USA.
12Hawaii Permanente Medical Group, Honolulu, HI, USA.
13Department of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.
PubMed PMC DOI PDF

Abstract

Suspected infection requiring hospitalisation has highly heterogenous presentation. Yet, variances in host response and its implications are largely unknown. In this multicentre cohort of 3802 individual patients presenting to the Emergency Department (ED) with suspected infection requiring hospitalisation, we apply uniform manifold approximation and projections and K-means clustering to 29 plasma…

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