Dynamics of the EZ/RPE Loss Ratio on OCT Over Time During Geographic Atrophy Progression and Treatment With Pegcetacoplan.

Julia Mai¹, Gregor S Reiter¹, Sophie Riedl¹, Wolf-Dieter Vogl², Amir Sadeghipour², Alex McKeown³, Emma Foos³, Hrvoje Bogunovic⁴, Ursula Schmidt-Erfurth¹

¹OPTIMA - Laboratory for Ophthalmic Image Analysis, Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria.

²RetInSight, Vienna, Austria.

³Apellis Pharmaceuticals, Boston, Massachusetts, United States.

⁴Institute of Artificial Intelligence / Center for Medical Data Science, Medical University of Vienna, Vienna, Austria.

PubMed PMC DOI PDF

Abstract

PURPOSE: The purpose of this study was to investigate the change of ellipsoid zone (EZ)/retinal pigment epithelium (RPE) loss ratio on optical coherence tomography (OCT) in geographic atrophy (GA) secondary to age-related macular degeneration using deep learning-based analysis. METHODS: OCT volumes of patients from the OAKS (NCT03525613) and DERBY (NCT03525600) trials, two phase III prospective r…

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