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Peer-Reviewed Publication
Nat Biotechnol2025;43(9):1416-1418.September 1, 2025Journal Article

Redefining druggable targets with artificial intelligence.

Karen Akinsanya1, Mohammed AlQuraishi2, Ann Boija3, John Chodera4, Anna Cichońska5, Marzyeh Ghassemi6, Martha Head7, Wengong Jin8, Warren A Kibbe9, Nevan Krogan10, Michael V LeVine11, John Moult12, Lynda Stuart13, Georgia Tourassi14, James Zou15, Regina Barzilay16, Olivier Elemento17
1Schrödinger, New York, NY, USA.
2Department of Systems Biology, Columbia University, New York, NY, USA.
3Dewpoint Therapeutics, Boston, MA, USA.
4Memorial Sloan Kettering Cancer Center, New York, NY, USA.
5Harmonic Discovery, New York, NY, USA.
6Massachusetts Institute of Technology, Cambridge, MA, USA.
7Amgen, Cambridge, MA, USA.
8Khoury College of Computer Science, Northeastern University, Boston, MA, USA.
9National Cancer Institute, Bethesda, MD, USA.
10University of California San Francisco, San Francisco, CA, USA.
11Genesis Therapeutics, Burlington, CA, USA.
12University of Maryland, College Park, MD, USA.
13Institute for Protein Design, Seattle, WA, USA.
14Oak Ridge National Laboratory, Oak Ridge, TN, USA.
15Stanford University, Stanford, CA, USA.
16Massachusetts Institute of Technology, Cambridge, MA, USA. regina@csail.mit.edu.
17Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA. ole2001@med.cornell.edu.

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