Implementation of Doxy-PEP in a Diverse Sexual Health Program in Northern Manhattan: The Doxy-Care Study.

Simian Huang¹, Caroline Carnevale¹, Natalie Neu¹, Joshua Klein¹, Daniela Quigee¹, Edward Perez¹, Lauren Burrell¹, Kathrine Meyers¹, Jacob McLean¹, Magdalena E Sobieszczyk¹, Delivette Castor¹, Jason Zucker¹

¹Simian Huang, Joshua Klein, Daniela Quigee, Kathrine Meyers, Jacob McLean, Magdalena E. Sobieszczyk, Delivette Castor, and Jason Zucker are with the Division of Infectious Diseases, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY. Natalie Neu is with the Division of Infectious Diseases, Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons. Caroline Carnevale, Edward Perez, and Lauren Burrell are with New York‒Presbyterian Hospital, New York, NY.

PubMed PMC DOI PDF

Abstract

This prospective cohort study evaluated the real-world effectiveness of doxycycline postexposure prophylaxis use in reducing bacterial sexually transmitted infections (STIs) within a diverse urban sexual health program. Propensity-matched analyses showed significant STI reductions, particularly in rectal Chlamydia trachomatis infections, among early adopters. Uptake was disproportionately higher i…

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