Multimodal AI correlates of glucose spikes in people with normal glucose regulation, pre-diabetes and type 2 diabetes.

Mattia Carletti¹, Jay Pandit¹, Matteo Gadaleta¹, Danielle Chiang¹, Felipe Delgado¹, Katie Quartuccio¹, Brianna Fernandez¹, Juan Antonio Raygoza Garay¹, Ali Torkamani¹, Riccardo Miotto², Hagai Rossman³, Benjamin Berk⁴, Katie Baca-Motes^1,4, Vik Kheterpal⁴, Eran Segal⁵, Eric J Topol¹, Edward Ramos^6,7, Giorgio Quer⁸

¹Scripps Research Translational Institute, La Jolla, CA, USA.

²Tempus AI, Chicago, IL, USA.

³Pheno.AI, Tel-Aviv, Israel.

⁴CareEvolution, Ann Arbor, MI, USA.

⁵Weizmann Institute, Rehovot, Israel.

⁶Scripps Research Translational Institute, La Jolla, CA, USA. eramos@scripps.edu.

⁷CareEvolution, Ann Arbor, MI, USA. eramos@scripps.edu.

⁸Scripps Research Translational Institute, La Jolla, CA, USA. gquer@scripps.edu.

PubMed PMC DOI PDF

Abstract

Type 2 diabetes (T2D) is a multifaceted disease associated with several factors, including diet, genetics, exercise, sleep and gut microbiome. Current diagnostic and monitoring methods based on episodic assays like glycated hemoglobin (HbA1c) fail to capture its full complexity. Here, in a prospective cohort of 1,137 participants in the United States, we analyzed multimodal data from 347 deeply ph…

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Mentioned Companies

Tempus
affiliation

NIH Funding

Grant #11362328
Scripps Clinical and Translational Science Hub
SCRIPPS RESEARCH INSTITUTE, THE
$6,074,495 (FY2026)

Other Funding

NCATS NIH HHS(UM1 TR004407)
United States
U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS)(UM1TR004407)

MeSH Terms

Humans0Diabetes Mellitus, Type 2*Prediabetic State*Female0Male0Middle Aged0Blood Glucose*Glycated Hemoglobin0Gastrointestinal Microbiome0Prospective Studies0Adult0Aged0Hypoglycemia0

Article Info

PMID: 40745404
PMCID: PMC12443610
DOI: 10.1038/s41591-025-03849-7
Received: September 25, 2024
Accepted: June 19, 2025

How to Cite

Carletti M et al. Multimodal AI correlates of glucose spikes in people with normal glucose regulation, pre-diabetes and type 2 diabetes. Nat Med2025;31(9):3121-3127. doi:10.1038/s41591-025-03849-7

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