Peer-Reviewed Publication
NPJ Digit Med2025;8(1):480.July 26, 2025Journal Article

AI-driven preclinical disease risk assessment using imaging in UK biobank.

Dmitrii Seletkov1,2, Sophie Starck3, Tamara T Mueller3, Yundi Zhang3, Lisa Steinhelfer4, Daniel Rueckert3,5, Rickmer Braren4,6
1Institute of Diagnostic and Interventional Radiology, Technical University of Munich School of Medicine, Munich, Germany. dmitrii.seletkov@tum.de.
2Chair for AI in Healthcare and Medicine, Technical University of Munich (TUM) and TUM University Hospital, Munich, Germany. dmitrii.seletkov@tum.de.
3Chair for AI in Healthcare and Medicine, Technical University of Munich (TUM) and TUM University Hospital, Munich, Germany.
4Institute of Diagnostic and Interventional Radiology, Technical University of Munich School of Medicine, Munich, Germany.
5Department of Computing, Imperial College London, London, UK.
6German Cancer Consortium (DKTK), Munich partner site, Heidelberg, Germany.

Abstract

Identifying disease risk and detecting disease before clinical symptoms appear are essential for early intervention and improving patient outcomes. In this context, the integration of medical imaging in a clinical workflow offers a unique advantage by capturing detailed structural and functional information. Unlike non-image data, such as lifestyle, sociodemographic, or prior medical conditions, w…

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