Clinical burden of major depressive disorder with versus without prominent anhedonia using a real-world electronic health records and claims linked database.

Hrishikesh Kale¹, Stevan Geoffrey Severtson², Becca S Feldman³, Tiina Drissen¹, Nilanjana Dwibedi¹, Andrew J Cutler⁴, Carl D Marci^3,5

¹Johnson & Johnson, Titusville, NJ, USA.

²OM1, Inc., Boston, MA, USA. gsevertson@om1.com.

³OM1, Inc., Boston, MA, USA.

⁴SUNY Upstate Medical University, Lakewood Ranch, FL, USA.

⁵Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

PubMed PMC DOI PDF

Abstract

BACKGROUND: Anhedonia is a core feature of major depressive disorder (MDD), yet the clinical burden in real-world settings is not well understood. This retrospective cohort study assessed depression symptoms and treatment patterns among patients with MDD with and without prominent anhedonia. METHODS: Patients with MDD were selected from a real-world dataset of electronic health records from mental…

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