Towards rapid and efficient simulation-free radiotherapy: MR guided adaptive prostate radiotherapy on the MR-Linac using diagnostic MRI reference planning.

Joan Chick¹, Francis Casey², Sian Cooper³, Trina Herbert⁴, Sophie Alexander⁵, Norina Predescu⁶, Szabolcs-Botond Lőrincz-Molnár⁷, Simeon Nill⁸, Uwe Oelfke⁹, Alison Tree¹⁰, Alex Dunlop¹¹

¹The Joint Department of Physics, The Royal Marsden Hospital and the Institute of Cancer Research, London, UK. Electronic address: joan.chick@rmh.nhs.uk.

²The Joint Department of Physics, The Royal Marsden Hospital and the Institute of Cancer Research, London, UK. Electronic address: Francis.Casey@rmh.nhs.uk.

³Royal Marsden NHS Foundation Trust and Institute of Cancer Research, London, UK. Electronic address: Sian.Cooper@rmh.nhs.uk.

⁴Royal Marsden NHS Foundation Trust, London, UK. Electronic address: Trina.Herbert@rmh.nhs.uk.

⁵Royal Marsden NHS Foundation Trust, London, UK. Electronic address: Sophie.Alexander@rmh.nhs.uk.

⁶MVision AI, Helsinki, Finland. Electronic address: Norina.Predescu@mvision.ai.

⁷MVision AI, Helsinki, Finland. Electronic address: szabolcs.lorincz@mvision.ai.

⁸The Joint Department of Physics, The Royal Marsden Hospital and the Institute of Cancer Research, London, UK. Electronic address: Simeon.Nill@icr.ac.uk.

⁹The Joint Department of Physics, The Royal Marsden Hospital and the Institute of Cancer Research, London, UK. Electronic address: Uwe.Oelfke@icr.ac.uk.

¹⁰Royal Marsden NHS Foundation Trust and Institute of Cancer Research, London, UK. Electronic address: Alison.Tree@rmh.nhs.uk.

¹¹The Joint Department of Physics, The Royal Marsden Hospital and the Institute of Cancer Research, London, UK. Electronic address: Alex.Dunlop@rmh.nhs.uk.

PubMed DOI

Abstract

BACKGROUND AND PURPOSE: Simulation-free radiotherapy offers improved efficiency for adaptive treatments. This planning study presents a simulation-free pre-treatment workflow for prostate cancer online adaptive radiotherapy on a MR-Linac. Previously acquired diagnostic MR images are used to create a reference treatment plan without clinician input, and adapted plans are then simulated, and compare…

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