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Peer-Reviewed Publication
J Med Internet Res2025;27e63343.July 11, 2025Journal Article

Standardizing Survey Data Collection to Enhance Reproducibility: Development and Comparative Evaluation of the ReproSchema Ecosystem.

Yibei Chen1, Dorota Jarecka1, Sanu Ann Abraham2, Remi Gau3, Evan Ng4, Daniel M Low1, Isaac Bevers1, Alistair Johnson1, Anisha Keshavan5, Arno Klein6, Jon Clucas6, Zaliqa Rosli7, Steven M Hodge8, Janosch Linkersdörfer9, Hauke Bartsch10, Samir Das11, Damien Fair12,13,14, David Kennedy8, Satrajit S Ghosh1,15
1McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, United States.
2Flexxbotics Inc, Boston, MA, United States.
3Neuro Data Science ORIGAMI Laboratory, McConnell Brain Imaging Centre, Faculty of Medicine, McGill University, Montréal, QC, Canada.
4The Hospital for Sick Children, Toronto, ON, Canada.
5BigHat Biosciences, San Mateo, CA, United States.
6Child Mind Institute, New York, NY, United States.
7McGill Centre for Integrative Neuroscience, Montréal Neurological Institute-Hospital, Montréal, QC, Canada.
8Department of Psychiatry, University of Massachusetts Chan Medical School, Worcester, MA, United States.
9Center for Human Development, University of California, San Diego, San Diego, CA, United States.
10Department of Informatics, University of Bergen, Bergen, Norway.
11McConnell Brain Imaging Center, McGill Centre for Integrative Neuroscience, Montréal Neurological Institute, McGill University, Montréal, QC, Canada.
12Institute of Child Development, University of Minnesota, Minneapolis, MN, United States.
13Department of Pediatrics, University of Minnesota, Minneapolis, MN, United States.
14Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, United States.
15Department of Otolaryngology, Harvard Medical School, Cambridge, MA, United States.
PubMed PMC DOI PDF

Abstract

BACKGROUND: Inconsistencies in survey-based (eg, questionnaire) data collection across biomedical, clinical, behavioral, and social sciences pose challenges to research reproducibility. ReproSchema is an ecosystem that standardizes survey design and facilitates reproducible data collection through a schema-centric framework, a library of reusable assessments, and computational tools for validation…

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