Peer-Reviewed Publication
Invest Ophthalmol Vis Sci2025;66(9):27.July 1, 2025Journal Article
Superficial Retinal Intercapillary Oxygen Diffusion and Perfusion Deficit Alterations in Patients With Coronary Artery Disease.
Natasa Jeremic1,2, Meltem Esengönül1,3, Azin Zarghami2, Maximilian Pawloff1,2, Matthias Hasun4, Markus Schreiner5, Reinhard Windhager5, Alexander Niessner4, Andreas Pollreisz2, Hrvoje Bogunovic1,3, Ursula Schmidt-Erfurth1,2
1Laboratory for Ophthalmic Image Analysis (OPTIMA), Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria.
2Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria.
3Christian Doppler Laboratory for Artificial Intelligence in Retina, Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria.
4Department of Internal Medicine II, Division of Cardiology, Clinic Landstraße, Vienna, Austria.
5Department of Orthopedics and Trauma-Surgery, Medical University of Vienna, Vienna, Austria.
Abstract
PURPOSE: Retinal imaging may offer a non-invasive method to detect coronary artery disease (CAD). Geometric perfusion deficits (GPDs), defined as intercapillary areas beyond 30 µm from the nearest vessel, were analyzed for their CAD association and topographical patterns.
METHODS: Patients undergoing coronary angiography and healthy controls (mean ages: non-CAD, 58 ± 9 years; CAD, 61 ± 9 years) w…
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