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Peer-Reviewed Publication
Epidemiol Rev2025;47(1)January 10, 2025Journal Article

Modifiable risk factors for sleep apnea: evidence from meta-analysis of traditional observational studies and 2-sample mendelian randomization.

Jia Wen Xu1, Hui Jun Yue2, Yu Zhang Huang3,4, Hao Wu5,6, Hui Min Su1, Mei Jiao Li1, Xue Qing Deng1, Jing Hong Liang1, Adrian I Campos7,8, Miguel E Rentería8,9, Lin Yang10,11, Lin Xu1,12,13, Jiao Wang1,13
1School of Public Health, Sun Yat-sen University, Guangzhou, China.
2Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
3Health Policy Department, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, United States.
4Shenzhen United Family Hospital, Shenzhen, China.
5Shenzhen Ninenovo Technology Limited, Shenzhen, China.
6RingConn LLC, Wilmington, DE, United States.
7Regeneron Genetics Center, Tarrytown, NY, USA.
8Mental Health & Neuroscience Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
9School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.
10School of Nursing, The Hong Kong Polytechnic University, Hong Kong SAR, China.
11Research Centre of Textiles for Future Fashion, The Hong Kong Polytechnic University, Hong Kong SAR, China.
12School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
13Greater Bay Area Public Health Research Collaboration.
PubMed DOI

Abstract

Epidemiologic studies have linked several modifiable factors to the risk of sleep apnea (SA). However, which specific factors affect the risk of SA and the strength of these effects are unclear. We conducted meta-analyses based on cross-sectional, cohort, and case-control studies found in the PubMed, Scopus, and Web of Science databases up to August 1, 2023. Studies that reported 1 of the associat…

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