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Peer-Reviewed Publication
Cureus2025;17(6):e85330.June 1, 2025Editorial

The Evolution of Do-It-Yourself Brain Hacking: From Fringe to Frontier.

Shaheen E Lakhan1,2,3,4,5
1Medical Office, Click Therapeutics, Inc., New York, USA.
2Department of Neurology, Western University of Health Sciences, Pomona, USA.
3Department of Neurology, A.T. Still University School of Osteopathic Medicine in Arizona, Mesa, USA.
4Department of Neurology, Morehouse School of Medicine, Atlanta, USA.
5Department of Bioscience, Global Neuroscience Initiative Foundation, Miami, USA.

Abstract

Do-it-yourself (DIY) brain hacking has evolved from fringe experimentation to a cultural and clinical phenomenon reshaping how individuals interact with their brains. From early self-directed use of racetam nootropics, at-home transcranial direct current stimulation, and meditation apps, to the normalization of microdosing psychedelics, this movement reflects a broader shift toward brain self-opti…

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