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Peer-Reviewed Publication
Circ Cardiovasc Imaging2025;18(8):e018059.August 1, 2025Journal Article

Novel CAC Dispersion and Density Score to Predict Myocardial Infarction and Cardiovascular Mortality.

Gavin Huangfu1,2,3, Abdul R Ihdayhid1,3,4, Simon Kwok5, John Konstantopoulos5, Kai Niu5, Juan Lu2, Harry Smallbone1,2, Gemma A Figtree6, Clara K Chow6, Lawrence Dembo1,7, Brendan Adler7, Christian Hamilton-Craig8, Stuart M Grieve6, Matthew T V Chan9, Craig R Butler10, Vikas Tandon11, Peter Nagele12, Pamela K Woodard13, Marko Mrkobrada14, Wojciech Szczeklik11,15,16, Yang Faridah Abdul Aziz17, Bruce Biccard18, Philip James Devereaux11, Tej Sheth11, Girish Dwivedi1,2,3,19,20, Benjamin J W Chow19
1Department of Cardiology, Fiona Stanley Hospital, Perth, WA, Australia (G.H., A.R.I., H.S., L.D., G.D.).
2Medical School, The University of Western Australia, Perth (G.H., J.L., H.S., G.D.).
3Harry Perkins Institute of Medical Research, Murdoch, WA, Australia (G.H., A.R.I., G.D.).
4Faculty of Health Sciences, Curtin University, Bentley, WA, Australia (A.R.I.).
5Artrya Ltd, Perth, WA, Australia (S.K., J.K., K.N.).
6Faculty of Medicine and Health, University of Sydney, NSW, Australia (G.A.F., C.K.C., S.M.G.).
7Envision Medical Imaging, Perth, WA, Australia (L.D., B.A.).
8Faculty of Medicine, University of Queensland, Brisbane, Australia (C.H.-C.).
9Department of Anaesthesia and Intensive Care, Chinese University of Hong Kong, China (M.T.V.C.).
10Department of Medicine, Division of Cardiology, University of Alberta, Edmonton, Canada (C.B.).
11Department of Medicine, McMaster University, Hamilton, ON, Canada (V.T., W.S., P.J.D., T.S.).
12Department of Anesthesia and Critical Care, The University of Chicago, IL (P.N.).
13Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO (P.K.W.).
14Division of General Internal Medicine, Western University, London, ON, Canada (M.M.).
15Center for Intensive Care and Perioperative Medicine, Jagiellonian University Medical College, Kraków, Poland (W.S.).
16Intensive Care and Anaesthesiology Department, 5th Military Hospital, Kraków, Poland (W.S.).
17Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia (Y.F.A.A.).
18Department of Anaesthesia and Perioperative Medicine, University of Cape Town, South Africa (B.B.).
19Departments of Medicine and Radiology, University of Ottawa Heart Institute, ON, Canada (G.D., B.J.W.C.).
20Victor Chang Cardiac Research Institute, Crawley, WA, Australia (G.D.).
PubMed DOI

Abstract

BACKGROUND: Coronary artery calcification (CAC) provides robust prediction for major adverse cardiovascular events (MACE), but current techniques disregard plaque distribution and protective effects of high CAC density. We investigated whether a novel CAC-dispersion and density (CAC-DAD) score will exhibit superior prognostic value compared with the Agatston score (AS) for MACE prediction. METHOD…

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