Flexible microfluidics-integrated electrochemical system for detection of tumor necrosis factor-alpha under continuous flow of sweat.

M Ploner¹, B Shkodra², L Franchin³, A Altana⁴, M Petrelli², M A Costa Angeli², G Ciccone², T Antrack⁵, L Vanzetti⁶, R R Nair⁵, R Canteri⁶, S Bonaldo³, A Paccagnella³, H Kleemann⁷, D Resnati⁸, P Lugli⁴, A Erten⁹, L Petti¹⁰

¹Sensing Technologies Laboratory (STL), Faculty of Engineering, Free University of Bozen- Bolzano, Bozen, 39100, Italy. Electronic address: moritz.ploner@student.unibz.it.

²Sensing Technologies Laboratory (STL), Faculty of Engineering, Free University of Bozen- Bolzano, Bozen, 39100, Italy.

³Biodevices Lab, Department of Information Engineering, University of Padova, Padova, 35122, Italy.

⁴Sensing Technologies Laboratory (STL), Faculty of Engineering, Free University of Bozen- Bolzano, Bozen, 39100, Italy; Competence Center for Mountain Innovation Ecosystems, Free University of Bozen- Bolzano, Bozen, 39100, Italy.

⁵Integrated Center for Applied Physics and Photonic Materials (IAPP), Technische Universität Dresden, Dresden, 01187, Germany.

⁶Center for Sensors and Devices, Fondazione Bruno Kessler (FBK), Povo, 38123, Italy.

⁷Integrated Center for Applied Physics and Photonic Materials (IAPP), Technische Universität Dresden, Dresden, 01187, Germany; Nano and Microelectronic System (NMES), Technische Universität Ilmenau, Ilmenau, 98693, Germany.

⁸Empatica Srl, Milano, 20144, Italy.

⁹Department of Electronics and Communication Engineering, Istanbul Technical University, Istanbul, 34485, Turkey.

¹⁰Sensing Technologies Laboratory (STL), Faculty of Engineering, Free University of Bozen- Bolzano, Bozen, 39100, Italy. Electronic address: luisa.petti@unibz.it.

PubMed DOI

Abstract

Cytokines play a vital role in immune system signaling, making their detection crucial for continuous health monitoring. Among the various cytokines, tumor necrosis factor-alpha (TNF-α) stands out as a key regulator of the immune response. Notably, TNF-α can be detected in sweat at concentrations as low as pg/mL, with levels strongly correlated with those in blood. Despite its importance, sensitiv…

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