Health AI Central
Peer-Reviewed Publication
NPJ Genom Med2025;10(1):50.July 1, 2025Journal Article

Geno4ME Study: implementation of whole genome sequencing for population screening in a large healthcare system.

Isabelle A Lucas Beckett1,2, Kate R Emery1, Josiah T Wagner1, Kathleen Jade2, Benjamin A Cosgrove1, John Welle1, J B Rinaldi3, Lindsay Dickey3, Kyle Jones3, Nick Wagner1, Eric M Shull1, Jon Clemens1, Kalliopi Trachana2,4, Lance Anderson1, Allison Kudla2, Brett Smith2, Hakon Verespej2, Li Chi Yuan1, Elizabeth Denne5,6, Erica Ramos5,7, Jennifer C Lovejoy2,8, Krzysztof Olszewski9,10, Martin G Reese9, Misty J Reynolds1, Mandy M Miller1, Alexa K Dowdell1, Brianna Beck1, James M Scanlan1, Mary B Campbell1, Andrew T Magis2, Keri Vartanian3, Brian D Piening1, Carlo B Bifulco1, Ora K Gordon11,12
1Providence Health and Services, Renton, WA, USA.
2Institute For Systems Biology, Seattle, WA, USA.
3Center for Outcomes Research and Education, Portland, OR, USA.
4Illumina, San Diego, CA, USA.
5Genome Medical, South San Francisco, San Francisco, CA, USA.
6BillionToOne, Inc, Menlo Park, CA, USA.
7Alcance Genomics LLC, San Diego, CA, USA.
8Phenome Health, Seattle, WA, USA.
9Fabric Genomics, Oakland, CA, USA.
10Genetic Intelligence Inc, Windsor, CA, USA.
11Providence Health and Services, Renton, WA, USA. ora.gordon@providence.org.
12Saint John Cancer Institute (John Wayne Cancer Institute), Santa Monica, CA, USA. ora.gordon@providence.org.
PubMed PMC DOI PDF

Abstract

The Genomic Medicine for Everyone (Geno4ME) study was established across the seven-state Providence Health system to enable genomics research and genome-guided care across patients' lifetimes. We included multi-lingual outreach to underrepresented groups, a novel electronic informed consent and education platform, and whole genome sequencing with clinical return of results and electronic health re…

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