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Peer-Reviewed Publication
JACC Heart Fail2025;13(8):102513.August 1, 2025Journal Article

Noninvasive Pulmonary Capillary Wedge Pressure Estimation in Heart Failure Patients With the Use of Wearable Sensing and AI.

Liviu Klein1, Marat Fudim2, Mozziyar Etemadi3, Robert Gordon4, Anjan Tibrewala5, Jaime Hernandez-Montfort6, Patrick McCann7, Lucas Zier8, Kevin Shah9, Allman Rollins10, Darshak Karia11, Arshed Quyyumi12, Shweta R Motiwala13, Nikolaos Diakos14, John Rommel15, Andrew P Ambrosy16, Venu G Ganti17, Priyanka Soni18, Karen Larimer17, Andrew M Carek17, Omer T Inan19
1Division of Cardiology and Advanced Heart Failure Comprehensive Care Center, University of California-San Franciso, San Francisco, California, USA. Electronic address: liviu.klein@ucsf.edu.
2Duke Clinical Research Institute, Durham, North Carolina, USA; Division of Cardiology, Duke University Medical Center, Durham, North Carolina, USA.
3Northwestern Medicine, Chicago, Illinois, USA; Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA; McCormick School of Engineering, Northwestern University, Evanston, Illinois, USA.
4Endeavor Health, NorthShore, Evanston, Illinois, USA.
5Northwestern Medicine, Chicago, Illinois, USA; Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
6Baylor, Scott and White, Temple, Texas, USA.
7Prisma Health Richland Hospital Medical Center, Columbia, South Carolina, USA.
8Division of Cardiology, Zuckerberg San Francisco General, San Francisco, California, USA; Division of Clinical Informatics and Digital Transformation, University of California, San Francisco, California, USA.
9University of Utah, Salt Lake City, Utah, USA.
10Inova Fairfax Medical Campus, Falls Church, Virginia, USA.
11Piedmont Augusta, Augusta, Georgia, USA.
12Emory University, Atlanta, Georgia, USA.
13Division of Cardiology and Advanced Heart Failure Comprehensive Care Center, University of California-San Franciso, San Francisco, California, USA.
14Texas Heart Institute, Houston, Texas, USA.
15Novant Health, Wilmington, North Carolina, USA.
16Kaiser Permanente Division of Research, San Francisco, California, USA; Division of Research, Kaiser Permanente Northern California, Pleasanton, California, USA.
17Cardiosense, Chicago, Illinois, USA.
18datAIsm Services, Pune, India.
19Cardiosense, Chicago, Illinois, USA; Georgia Institute of Technology, Atlanta, Georgia, USA. Electronic address: inan@gatech.edu.
PubMed DOI

Abstract

BACKGROUND: Remote hemodynamics-guided management of heart failure (HF) with implantable pulmonary artery pressure sensors has been shown to reduce HF hospitalizations. The widespread clinical adoption of this procedure is constrained by its invasive nature and high cost. We present a noninvasive technology based on a wearable sensor (CardioTag; Cardiosense) and machine learning (ML) for estimatin…

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